The 18th puzzle is called "Synapses". See how to solve it in Assassin's Creed 2. Code wheel puzzle: Your first clue is to line up 5 with a single tree-looking symbol. The key here is the weird-looking equation on the left, which offers a hint as to the progression of the symbols.
Image: In what's sure to be a relief after the last puzzle, all you need to do here is move the cursor to light up the neurotransmitters. For more info, watch the whole gameplay.
This is an Assassin's Creed II walkthrough for Glyph Puzzle #18. The Glyph Puzzles can actually be some of the hardest challenges the game will throw your way. Keep in mind that the puzzles will be made available to you in the same order, regardless of which Glyphs you find first.
Mahalo's Assassins Creed 2 Walkthroughs are more than enough information for you to play the game yourself, and they teach you everything your need to be prepared for when playing yourself. This video walkthrough focuses on Glyph Puzzle 18.
Assassin's Creed 2 by Ubisoft is the action-adventure video game playable on PlayStation 3, Xbox 360, Sony PSP, and Nintendo DS video game consoles, along with Microsoft Windows. It is the direct sequel of Assassin's Creed and revolves around Ezio, and is set in Renaissance Italy. Ezio befriends Leonardo da Vinci, who provides experimental weapons and gadgets, and takes on Florence's most powerful families and ventures throughout the canals of Venice, where he learns to become a master assassin. The Assassin's Creed 2 gameplay is a mixture of action, stealth, and acrobatics.